Zandra Hillis and Cassie Brenner needed help. Zandra had lost her six figure job on Wall Street when the market crashed, and Cassie's husband had run off with his nubile assistant, leaving her with a half-renovated Victorian and two children. She quit her job as an accountant and she and Zandra formed SuperGirls, an agency whose motto was 'We'll do anything as long as it's legal'.

When Pal is charged with the murder, Cassie and Zandra are convinced he is innocent, though they have no evidence of this. They enlist the aid of Rob, and plunge into a maelstrom of serial murders, avenging Fundamentalist Christians and Moslems, and are quickly in over their heads. This delights Rob, whose magazine, Conspiracy, is notorious for exposes of the powerful and conscienceless.

As SuperGirls grows, Zandra's father Stan comes to join them after leaving his wife Zelda. Zelda, always a rather strange woman, has gone off the deep end and joined a mysterious cult-like church called The Church of Everlasting Enlightenment and Chastisement, run by a ludicrous figure of a man named The Reverend Billy-Bob Savage. Stan moves into the carriage house behind 'Wisteria Manor', and sets in to enlarge the roster of jobs SuperGirls takes in.

Cassie's two children, an adopted black boy named Daniel and a baby named Jamie, are so drawn to Zandra and Stan that they become extended family. When Pal proposes to Cassie, Daniel decides his life is just about perfect, until he and Jamie are kidnapped by some men sent by the Reverend Billy Bob. What is the role of the Church in the serial deaths of college co-eds? How did the Christians and Moslems join forces to wipe out young women who spoke against their tenets? How can they be stopped by two young career women, a college professor and a magazine editor?

By the end of the book Cassie and Pal are wed, Zandra has gotten her own place to live and Rob is pestering her to live with him, and heroes are born in the unlikeliest places.